TPF may refer to:

• Tibial plateau fracture
• Theodore Payne Foundation for Wild Flowers and Native Plants
• Transaction Processing Facility, an operating system by IBM
• Terrestrial Planet Finder, a proposed system of telescopes to detect extrasolar planets
• The Pop Factory, a Welsh television program
• The Perl Foundation, a non-profit organization
• The Proud Family, a Disney Channel Original Series
• Tapered-polymer-fiber, a type of laser
• Docetaxel, Cisplatin, and fluorouracil, a chemotherapy regimen used in head and neck cancer
• Tokyopop, a manga publishing company
• Telangana Praja Front, a political party
• Transports publics Fribourgeois, a public transport operator in the Swiss canton of Fribourg
• Tribunal pénal fédéral, the Swiss Supreme Court for criminal matters
• Peter O. Knight Airport, IATA airport code
• Tooting Popular Front, a fictional revolutionary organisation in Citizen Smith
• The Purse Forum, a popular online forum dedicated to the discussion of fashion and luxury goods
• National Treatment Purchase Fund, the Irish healthcare programme
• Tachi Palace Fights, an American Mixed Martial Arts promotion.
• Transport Fever, a computer game
• Tactical Patrol Force, slang term for riot control squad